Journal of Organic Chemistry p. 4750 - 4754 (1990)
Update date:2022-08-05
Topics:
Solladie-Cavallo, A.
Khiar, N.
Natural (2S,3R)-3-amino-2-hydroxy-5-methylhexanoic acid is synthesized in 53-55percent yield (referred to (-)-8-phenylmenthol used as chiral auxiliary) by condensation of 1-nitro-3-methylbutane on (-)-8-phenylmenthol glyoxylate hydrate using KF as a mild base.With a large excess of KF in THF it has been possible to increase the diastereoselectivity of the nitro aldol condensation (up to I/II/III/IV = 77/13/10/0).
View Morewebsite:http://www.sagechem.com
Contact:+86-571-86818502
Address:Room C1301, New Youth Plaza, 8 Jia Shan Road, Hangzhou, China
Jiangsu Institute of Ecomones Co., Ltd
website:http://www.jsmone.com
Contact:+86-519-82821700
Address:95 Huanyuan N. Road, Jintan, Jiangsu, China
Contact:+86-571-28186845
Address:Room 1224,Eastcom Mansion,398 Wensan Road,Hangzhou,310013 China
Contact:+86-310-7092106
Address:Quzhou Modern & New Industrial Park, Handan, Hebei 057250, China
Zhejiang Chemicals Import & Export Corporation (ZHECHEM)
Contact:+86-571-87046953
Address:No. 37, Qingchun Road
Doi:10.1016/0022-328X(90)85227-P
(1990)Doi:10.1002/anie.201005373
(2011)Doi:10.1016/j.ejmech.2019.04.006
(2019)Doi:10.1016/S0040-4020(01)81961-X
(1990)Doi:10.1021/jm061198m
(2007)Doi:10.1016/j.bmc.2015.05.018
(2015)
