EFFICIENT SYNTHESIS OF 1,2-seco AND 1,2-seco 2-nor PYRIMIDINE AND PURINE NUCLEOSIDES.

Article abstract of DOI:10.1016/S0040-4039(01)93332-5

Unprotected sylilated purines and pyrimidines (adenine, guanine, cytosine, thymine) reacted with acetoxymethyl ether (acyclic sugar analogues) under solid PTC conditions, using KI and dibenzo-18-crown-6 in benzene-acetonitrile(1:1, v/v) to give regiospecifically the corresponding N-9 purine and N-1 pyrimidine acyclic nucleosides in fairly good yields.