A Method to Accomplish a 1,4-Addition Reaction of Bulky Nucleophiles to Enones and Subsequent Formation of Reactive Enolates

Article abstract of DOI:10.1021/ol010071i

(matrix presented) BF₃-promoted 1,4-addition of bulky aryl groups to α-iodo enones, prepared from the parent enones, afforded β-aryl-α-iodo ketones. Subsequent reaction with EtMgBr furnished the magnesium enolates, which upon reactions with CIP