Introduction of Amino Groups Adjacent to Trifluoromethyl Groups in Heterocyclic Compounds; Synthesis of 5-Amino-4-trifluoromethylthiazoles

Article abstract of DOI:10.1055/s-1990-26877

On reaction of 5-fluoro-4-trifluoromethylthiazoles 5 with primary aromatic and heteroaromatic amines, in the presence of 4-dimethylaminopyridine, a transamination process occurs to yield 5-amino-4-trifluoromethylthiazoles 2.Likewise, compounds 2 are forme