European Journal of Medicinal Chemistry p. 187 - 190 (1990)
Update date:2022-08-05
Topics:
Andreani, Aldo
Rambaldi, Mirella
Locatelli, Alessandre
Bossa, Rosaria
Galatulas, Iraklis
Ninci, Mauro
The paper reports the synthesis of 3-(2,5-dimethoxybenzylidene)- 2 and 3-(4-pyridylmethylene)-2-indolinones 3 which, as expected, proved to have significant positive inotropic activity.On the contrary, 3-(2,5-dimethoxybenzyl)- 4 and 3-(4-pyridylmethyl)-2-indolinones 5, obtained by reduction of the corresponding compounds 2 and 3, were devoid of cardiotonic activity.
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(1989)
