Chemical and Pharmaceutical Bulletin p. 590 - 596 (1990)
Update date:2022-08-04
Topics:
Ono
Tamura
In acid hydrolysis of N1-acyl-N1,N2-diarylamidines, a water molecule attacked exclusively the amidine central carbon, and the reaction proceeded in parallel through two pathways. One of them leads to the formation of two N-acylarylamines, and the other leads to the formation of N,N-diacylarylamine and arylamine. Acid hydrolysis of N1-tosyl-N1,N2-diarylamidine was also examined. The results were similar to those of the hydrolysis of N1-acyl-N1,N2-diarylamidines. Alkaline hydrolysis and alcoholysis of N1-acyl-N1,N2-diarylamidines occurred almost exclusively at the amide carbonyl group to give N1,N2-diarylamidines and carboxylic acids or their esters. The effects of structural change and the aryl substituents on the rate and direction of the reaction were examined.
View Morewebsite:http://www.dulynet.com/
Contact:025-84699383 -8003
Address:Room 503, Building 2, Chuangxinhui, No. 61 Wenjing Road, High-tech Development Zone, Pukou District, Nanjing City, Jiangsu Province Nanjing, Jiangsu
website:http://www.antaibio.com
Contact:0086-21-65663057
Address:Room 2108, Building 2，No. 489 Zhengli Road，200433
ZUNYI CITY BEI YUAN CHEMICAL CO., LTD
website:http://www.china-beiyuan.com
Contact:+86-851-27751258
Address:Shawan Town, Huichuan District, Zunyi City, Guizhou Province, China
JiangXi Hong Run Chemical Co., Ltd
Contact:+86-0791-88521351
Address:XingHuo industrial zone in YongXiu county
Shanghai PotentPharm Science and Technology Co.,Ltd
Contact:86-021-51969655
Address:Unit B, Building 18, No.300, Chuantu Rd,Pudong District, Shanghai 201202, China
Doi:10.1016/S0040-4020(97)10337-4
(1998)Doi:10.1021/ol991271l
(2000)Doi:10.1021/jm00172a019
(1990)Doi:10.1021/jo200401a
(2011)Doi:10.1081/SCC-200054759
(2005)Doi:10.1021/ol200557r
(2011)
