Novel Acyl-CoA:Cholesterol Acyltransferase Inhibitors. Synthesis and Biological Activity of 3-Quinolylurea Derivatives

DOI: 10.1021/jm00039a020

Source and publish data:

Journal of Medicinal Chemistry p. 2079 - 2084 (1994)

Update date:2022-08-02

Topics:

Authors:

Tawada, Hiroyuki

Harcourt, Myles

Kawamura, Noriaki

Kajino, Masahiro

Ishikawa, Eiichiro

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00039a020

A series of 3-quinolylurea derivatives (1) was synthesized and evaluated for acyl-CoA:cholesterol acyltransferase (ACAT) inhibitory activity.For in vitro studies, the most potent inhibitory activity was found in derivatives having substituents at the 6,7-

Full text of DOI:10.1021/jm00039a020

Products guided by the article

Product name:3-amino-4-(2-chlorophenyl)-6,8-dimethylquinoline

Cas No:128831-37-8

R&D Labs maybe for 128831-37-8

Aqua Chem Industry Co., Ltd

Contact:+86-515-88356562

Address:No.2, West Daqing Road, Yancheng, Jiangsu, China
TAIZHOU XINGCHENG CHEMPHARM CO.,LTD.

Contact:0086-0576-88551200,88886292 ,88880039

Address:B Area. 10 Floor.Yaodadasha. 289#.Shifu Road.Taizhou.Zhejiang.China
Dongying J&M Chemical Co., Ltd,

Contact:546-8551108

Address:Room 1219, Zisheng Mansion, Zibo Road, Dongying, Shandong, China
Changzhou Foreign Trade Corp

Contact:+86-519-86623222

Address:29F/D, 99 Yanling West Road, Changzhou, Jiangsu, China
AURORA CHEMICAL CO., LTD

Contact:86-532-68629711 13780605697

Address:NO 220 YANAN 3 ROAD,(POST ADMINISTRATION BUILDING),QINGDAO,CHINA

Relevant to this article

A novel donor-acceptor molecule containing a cyclic triphenylamine dimer: Synthesis, characterization, and application in memory device

Doi:10.1016/j.tet.2011.12.007
(2012)
Synthesis and Calibration of Two Radical Timing Devices: 2-Methyl-2-(1-naphthyl)- and 2-Methyl-2-(2-naphthyl)-1-bromopropane

Doi:10.1021/jo9813179
(1999)
Synthesis of an 1-azaglucose analogue with ring-oxygen retained

Doi:10.1016/S0040-4039(99)00423-2
(1999)
Chiral azole derivatives, 3¹. Synthesis of the enantiomers of the potent aromatase inhibitor 1-[2-benzofuranyl(4-chlorophenyl)methyl]-1H-imidazole

Doi:10.1016/S0040-4039(99)01569-5
(1999)
Azo-8-hydroxyquinoline dyes: The synthesis, characterizations and determination of tautomeric properties of some new phenyl- and heteroarylazo-8-hydroxyquinolines

Doi:10.1016/j.molliq.2014.02.027
(2014)
"Greener" Friedel-Crafts acylations: A metal- and halogen-free methodology

Doi:10.1021/ol200482s
(2011)

Article Doi