Novel Acyl-CoA:Cholesterol Acyltransferase Inhibitors. Synthesis and Biological Activity of 3-Quinolylurea Derivatives

DOI: 10.1021/jm00039a020

Source and publish data:

Journal of Medicinal Chemistry p. 2079 - 2084 (1994)

Update date:2022-08-02

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Authors:

Tawada, Hiroyuki

Harcourt, Myles

Kawamura, Noriaki

Kajino, Masahiro

Ishikawa, Eiichiro

et al. et al.

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Article abstract of DOI:10.1021/jm00039a020

A series of 3-quinolylurea derivatives (1) was synthesized and evaluated for acyl-CoA:cholesterol acyltransferase (ACAT) inhibitory activity.For in vitro studies, the most potent inhibitory activity was found in derivatives having substituents at the 6,7-

Full text of DOI:10.1021/jm00039a020

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