Chiral azole derivatives, 31. Synthesis of the enantiomers of the potent aromatase inhibitor 1-[2-benzofuranyl(4-chlorophenyl)methyl]-1H-imidazole

Article abstract of DOI:10.1016/S0040-4039(99)01569-5

Starting from (+)- and (-)-1-(4-chlorophenyl)-2-propynylamine, in turn obtained by CAL-mediated kinetic resolution of the corresponding racemate, a stereoselective synthesis of both enantiomers of the title compound has been achieved.