Chemical Communications p. 3252 - 3254 (2009)
Update date:2022-08-02
Topics: Synthesis Diastereoselectivity Yield Catalyst Enantioselective Nuclear magnetic resonance (NMR) spectroscopy High-performance liquid chromatography (HPLC) Reaction Conditions Chiral molecule Palinurin
Perez, Manuel
Perez, Daniel I.
Martinez, Ana
Castro, Ana
Gomez, Generosa
Fall, Yagamare
The first enantioselective synthesis of palinurin has been accomplished starting from commercially available furaldehyde and (R)-methyl-3-hydroxy-2- methylpropionate; the key steps of the synthesis include the use of a chiral pyrrolidine to create the chiral tetronic moiety, and Horner-Wadsworth-Emmons, Wittig and Wittig-Horner reactions to construct the alkene units.
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