Synthesis, structure and biological activity of α-trifluoromethyl-substituted thyreotropin releasing hormone

DOI: 10.1016/S0022-1139(96)03461-6

Source and publish data:

Journal of Fluorine Chemistry p. 53 - 57 (1996)

Update date:2022-07-29

Topics:

Authors:

Koksch, Beate

Ullmann, Dirk

Jakubke, Hans-Dieter

Burger, Klaus

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Article abstract of DOI:10.1016/S0022-1139(96)03461-6

The incorporation of α-trifluoromethyl pyroglutamic acid into thyreotropin releasing hormone TRH, results in the complete stability of the pGlu-His bond against proteolytic degradation by pyroglutamyl aminopeptidase II. The influence of the trifluoromethy

Full text of DOI:10.1016/S0022-1139(96)03461-6

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