European Journal of Medicinal Chemistry p. 407 - 414 (1993)
Update date:2022-08-05
Topics:
Cutler
El-Kabbani
Keane
Fisher-Shore
McCabe
Johnson
DeWitt Blanton Jr.
Furan o-aminonitriles may be utilized as precursors in the synthesis of flavone-8-carboxylic acids. Some results from in vivo evaluation against P388 leukemia, colon carcinoma 38, and B16 melanoma models suggest that selected examples of the acids are potentially as effective as the antitumor compound, flavone acetic acid. The flavone-8-carboxylic acids did not exhibit significant activity against an in vitro HIV screen or an in vitro antitumor screen consisting of a cell panel of 60 lines.
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