Asymmetric Synthesis of β-Amino Acid Derivatives by Michael Addition to Chiral 2-Aminomethylacrylates

DOI: 10.1016/S0040-4039(00)91786-6

Source and publish data:

Tetrahedron Letters p. 1323 - 1326 (1993)

Update date:2022-08-02

Topics:

Authors:

Barnish, Ian T.

Corless, Martin

Dunn, Peter J.

Ellis, David

Finn, Paul W.

et al. et al.

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Article abstract of DOI:10.1016/S0040-4039(00)91786-6

The addition of lithium enolates to chiral aminomethylacrylates 7 and 8 proceeded with excellent diastereodifferentiation (up to 98percent de) and provided an expeditious synthesis of homochiral β-aminomethylglutarates 9 and 10, on a scale of up to 500g.T

Full text of DOI:10.1016/S0040-4039(00)91786-6

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