Asymmetric Synthesis of β-Amino Acid Derivatives by Michael Addition to Chiral 2-Aminomethylacrylates

Article abstract of DOI:10.1016/S0040-4039(00)91786-6

The addition of lithium enolates to chiral aminomethylacrylates 7 and 8 proceeded with excellent diastereodifferentiation (up to 98percent de) and provided an expeditious synthesis of homochiral β-aminomethylglutarates 9 and 10, on a scale of up to 500g.T