Importance of the Aromatic Ring in Adrenergic Amines. 7. Comparison of the Stereoselectivity of Norepinephrine N-Methyltransferase for Aromatic vs. Nonaromatic Substrates and Inhibitors

Article abstract of DOI:10.1021/jm00352a020

Some nonaromatic analogues of amphetamine and α-methylbenzylamine were prepared and evaluated as competitive inhibitors of norepinephrine N-methyltranspherase (NMT).All of the nonaromatic analogues were significantly more active than their aromatic counte