USE OF α-2-CYANOETHYL tert-BUTOXYCARBONYLASPARTATE AS AN INTERMEDIATE FOR SYNTHESIS OF β-ESTERS

Article abstract of DOI:10.1007/BF00607542

The use of α-2-cyanoethyl Boc-aspartate is proposed for the first time for the synthesis of β-esters of Boc-aspartic acid.The α-2-cyanoethyl protective group is selectively split out by strong organic bases under hydrolytic conditions without the β-ester bond being affected.Using the α-2-cyanoethyl derivative, β-cyclohexyl, β-benzyl, and β-tert-butyl Boc-aspartates have been synthesized in good yields.