Amodiaquine analogues containing NO-donor substructures: Synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria

DOI: 10.1016/j.ejmech.2011.02.029

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European Journal of Medicinal Chemistry p. 1757 - 1767 (2011)

Update date:2022-08-05

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Authors:

Bertinaria, Massimo

Guglielmo, Stefano

Rolando, Barbara

Giorgis, Marta

Aragno, Cristina

Fruttero, Roberta

Gasco, Alberto

Parapini, Silvia

Taramelli, Donatella

Martins, Yuri C.

Carvalho, Leonardo J.M.

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Article abstract of DOI:10.1016/j.ejmech.2011.02.029

The synthesis and physico-chemical properties of novel compounds obtained by conjugation of amodiaquine with moieties containing either furoxan or nitrooxy NO-donor substructures are described. The synthesised compounds were tested in vitro against both t

Full text of DOI:10.1016/j.ejmech.2011.02.029

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