An approach to the synthesis of the hexahydronaphthalene unit of pravastatin

DOI: 10.1016/0040-4039(90)80194-Q

Source and publish data:

Tetrahedron Letters p. 2235 - 2238 (1990)

Update date:2022-08-05

Topics: Hydrogenation Stereochemistry Control Ring Formation Functional Group Transformations Protecting group strategy Final Adjustments

Authors:

Barrish, Joel C.

Wovkulich, Peter M.

Tang, Peng Cho

Batcho, Andrew D.

Uskokovic, Milan R.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(90)80194-Q

The aldehyde 3b is prepared from (S)-pulegone (5) by a series of highly effective transformations, including a stereospecific [2,3]-Wittig rearrangement of the allyl ether of 6, stereoselective selenolactonization of 8c, SN2′ addition to 10 and a stereospecific intramolecular ene reaction of 11b.

Full text of DOI:10.1016/0040-4039(90)80194-Q

Products guided by the article

Product name:(R)-4-((S)-3-Allyl-4-methyl-cyclohex-1-enyl)-3-(tert-butyl-dimethyl-silanyloxy)-butyraldehyde

Cas No:130132-07-9

R&D Labs maybe for 130132-07-9

Ji'nan Orgachem Pharmaceutical Co.,Ltd

Contact:+86-531-82687810

Address:Jinan
Hangzhou Mole's Science & Technology Co.,Ltd.(expird)

Contact:+86-571-56880228

Address:15F Guodu development Building, NO.182 Zhaohui Road
Jiangsu Willing Bio-Tech Co ltd

website:http://www.willingbio.com/

Contact:+86 18796908173

Address:No 18 Guoqiao Road
Longhui qunfeng Chemical Co., Ltd

Contact:86-731-82173407

Address:South-east Industrial Park, Longhui County, Hunan Province, China
Xinjiang Zhongtai Chemical Co., Ltd.

Contact:+86-991-8788172

Address:NO.78 XISHAN RD.URUMQI，CHINA

Relevant to this article

Synthesis and derivatization of 8-acetylpsoralens. Acetyl migrations during Claisen rearrangement

Doi:10.1021/jo00164a015
(1983)
Enantioselective synthesis of homoallylic amines through reactions of (pinacolato)allylborons with aryl-, heteroaryl-, alkyl-, or alkene-substituted aldimines catalyzed by chiral C ₁-symmetric NHC-Cu complexes

Doi:10.1021/ja200311n
(2011)
Using peptidic inhibitors to systematically probe the S1′ site of caspase-3 and caspase-7

Doi:10.1021/ol051287d
(2005)
The reactivity, as electrogenerated bases, of chiral and achiral phenazine radical-anions, including application in asymmetric deprotonation

Doi:10.1039/b506309d
(2005)
Doi:10.1021/ja01597a049
(1956)
Acetylenic allenophanes: An asymmetric synthesis of a bis(alleno)- bis(butadiynyl)-metacyclophane

Doi:10.1002/anie.200500484
(2005)

Article Doi