G. Ahn et al. / Bioorg. Med. Chem. Lett. 21 (2011) 2259–2263
2263
13. Nagarajan, M.; Morrell, A.; Ioanoviciu, A.; Antony, S.; Kohlhagen, G.; Agama, K.
K.; Hollingshead, M.; Pommier, Y.; Cushman, M. J. Med. Chem. 2006, 49, 6283.
14. Morrell, A.; Antony, S.; Kohlhagen, G.; Pommier, Y.; Cushman, M. J. Med. Chem.
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15. Morrell, A.; Placzek, M.; Parmley, S.; Grella, B.; Antony, S.; Pommier, Y.;
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cies against Topo II and HL60 cell line. These results suggested that
Topo II inhibition may be favored with shorter N6 lactam side
chain. Lengthening the N6 side chain beyond three methylene
units proved to be deleterious to the Topo II inhibition activity.
No correlation has been observed between DNA binding ability,
Topo II inhibition and cytotoxicity, suggesting Topo II is not the
only mechanism involved in the antiproliferative activity.
16. Morrell, A.; Placzek, M.; Parmley, S.; Antony, S.; Dexheimer, T. S.; Pommier, Y.;
Cushman, M. J. Med. Chem. 2007, 50, 4419.
17. Pommier, Y.; Cushman, M. Mol. Cancer Ther. 2009, 8, 1008.
18. Ryckebusch, A.; Garcin, D.; Lansiaux, A.; Goossens, J. F.; Baldeyrou, B.; Houssin,
R.; Bailly, C.; Hénichart, J. P. J. Med. Chem. 2008, 51, 3617.
19. Ahn, G.; Lansiaux, A.; Goossens, J. F.; Bailly, C.; Baldeyrou, B.; Schifano-Faux, N.;
Grandclaudon, P.; Couture, A.; Ryckebusch, A. Bioorg. Med. Chem. 2010, 18,
8119.
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