N-[(ω-amino-1-hydroxyalkyl)phenyl]methanesulfonamide derivatives with Class III antiarrhythmic activity

DOI: 10.1021/jm00105a048

Source and publish data:

Journal of Medicinal Chemistry p. 308 - 315 (1991)

Update date:2022-08-04

Topics:

Authors:

Hester Hester

Gibson Gibson

Cimini Cimini

Emmert Emmert

Locker Locker

Perricone

Skaletzky

Sykes Sykes

West West

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Article abstract of DOI:10.1021/jm00105a048

N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide, (E)-2-butenedioate (2:1) salt (ibutilide fumarate, 2E), has been found to have Class III antiarrhythmic activity. In an in vitro rabbit heart tissue preparation designed to evaluate the

Full text of DOI:10.1021/jm00105a048

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