Diastereoselective Addition of Organometallics to Chiral α-Keto Amides Having trans-2,5-Disubstituted Pyrrolidine

DOI: 10.1246/cl.1990.1749

Source and publish data:

Chemistry Letters p. 1749 - 1752 (1990)

Update date:2022-08-05

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Authors:

Kawanami, Yasuhiro

Katayama, Koji

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Article abstract of DOI:10.1246/cl.1990.1749

The nucleophilic addition of organotitanium reagents to α-keto amides derived from (2R,5R)-trans-2,5-bis(t-butyldimethylsiloxymethyl)pyrrolidine <(R,R)-BTBSP> afforded the corresponding α-hydroxy amides with very high diastereofacial selectivity.

Full text of DOI:10.1246/cl.1990.1749

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Product name:(S)-1-[(2R,5R)-2,5-Bis-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-2-hydroxy-2-phenyl-propan-1-one

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