Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists

DOI: 10.1016/j.bmcl.2005.06.009

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 4136 - 4142 (2005)

Update date:2022-08-04

Topics:

Authors:

Lee, Jeewoo

Kang, Sang-Uk

Kil, Min-Jung

Shin, Myoungyoup

Lim, Ju-Ok

Choi, Hyun-Kyung

Jin, Mi-Kyoung

Kim, Su Yeon

Kim, Sung-Eun

Lee, Yong-Sil

Min, Kyung-Hoon

Kim, Young-Ho

Ha, Hee-Jin

Tran, Richard

Welter, Jacqueline D.

Wang, Yun

Szabo, Tamas

Pearce, Larry V.

Lundberg, Daniel J.

Toth, Attila

Pavlyukovets, Vladimir A.

Morgan, Matthew A.

Blumberg, Peter M.

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Article abstract of DOI:10.1016/j.bmcl.2005.06.009

The structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPV1 receptor antagonists. The 2-halogen analogues showed enhanced antagonism compared to the prototype antagonist.

Full text of DOI:10.1016/j.bmcl.2005.06.009

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