Synthesis, reactivity, and bioactivity of avermectin B1-3,4-oxide

DOI: 10.1016/S0040-4039(00)97779-7

Source and publish data:

Tetrahedron Letters p. 4965 - 4968 (1990)

Update date:2022-08-03

Topics:

Authors:

Blizzard, Timothy A.

Mrozik, Helmut

Preiser, Franz A.

Fisher, Michael H.

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Article abstract of DOI:10.1016/S0040-4039(00)97779-7

Avermectin B₁-3,4-oxide (2) has been synthesized from avermectin B₁ (1). While epoxide 2 is comparable to avermectin B₁ in bioactivity, opening of the epoxide leads to derivatives which are substantially less bioactive.

Full text of DOI:10.1016/S0040-4039(00)97779-7

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