Michael Addition of 2,2-Difluoroketene Silyl Acetal. Preparation of 4,4-Difluoroglutamic Acid and 5,5-Difluorolysine

DOI: 10.1246/cl.1990.1307

Source and publish data:

Chemistry Letters p. 1307 - 1310 (1990)

Update date:2022-07-29

Topics:

Authors:

Kitagawa, Osamu

Hashimoto, Akihiro

Kobayashi, Yoshiro

Taguchi, Takeo

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Article abstract of DOI:10.1246/cl.1990.1307

2,2-Difluoroketene Silyl Acetal, generated in situ by treating methyl difluoroiodoacetate with Zn followed by chlorosilane, readily reacted with α,β-unsaturated carbonyl compounds or acetals to give the 1,4-addition products, preferentially.The difluoro a

Full text of DOI:10.1246/cl.1990.1307

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