Michael Addition of 2,2-Difluoroketene Silyl Acetal. Preparation of 4,4-Difluoroglutamic Acid and 5,5-Difluorolysine

Article abstract of DOI:10.1246/cl.1990.1307

2,2-Difluoroketene Silyl Acetal, generated in situ by treating methyl difluoroiodoacetate with Zn followed by chlorosilane, readily reacted with α,β-unsaturated carbonyl compounds or acetals to give the 1,4-addition products, preferentially.The difluoro a