Synthesis and antirhinovirus activity of 8-substituted analogues of 6-(dimethylamino)-9-(4-methylbenzyl)-2-(trifluromethyl)-9H-purine

DOI: 10.1021/jm00105a023

Source and publish data:

Journal of Medicinal Chemistry p. 157 - 160 (1991)

Update date:2022-08-03

Topics:

Authors:

Kelley Kelley

Linn Linn

Selway Selway

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00105a023

Several 8-substituted analogues of 6-(dimethylamino)-9-(4-methylbenzyl)-2-(trifluoromethyl)-9H-purine (1) were synthesized and tested for activity against rhinovirus type 1B. Among 16 8-substituted analogues, the 8-amino (3) and 8-bromo (2) analogues were

Full text of DOI:10.1021/jm00105a023

Products guided by the article

Product name:[8-Bromo-9-(4-methyl-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-dimethyl-amine

Cas No:130934-04-2

R&D Labs maybe for 130934-04-2

Jinzhou Jiutai Pharmaceutical Co.,Ltd

Contact:+86-0416-5179890

Address:No.41, Taianli, Taihe District, Jinzhou, Liaoning
Xinchang Yueding Chemical Co., Ltd.

Contact:86-571-56926323

Address:NO.90 BEIMENCHENGWAI CHENGGUAN TOWN XINCHANG
Eastar Chemical Corporation

website:http://www.eastarchem.com/

Contact:1-800-898-2436

Address:1215 K Street, STE 1700
Sdow

website:http://www.sdowchem.com

Contact:86-135-2193 7483

Address:8-106 taiyue building
Shanghai SMEC Trading Co., Ltd.

website:http://www.shanghaismec.com

Contact:+86-21-68811293

Address:ROOM 1101,NO.800 SHANGCHENG RD,SHANGHAI,CHINA

Relevant to this article

Catalytic Enantioselective Protonation/Nucleophilic Addition of Diazoesters with Chiral Oxazaborolidinium Ion Activated Carboxylic Acids

Doi:10.1002/anie.201612655
(2017)
Organic reaction in water: A highly efficient and environmentally friendly synthesis of spiro compounds catalyzed by L -proline

Doi:10.1002/hlca.201000307
(2011)
Studying synergism of methyl linked cyclohexyl thiophenes with triazole: Synthesis and their cdk5/p25 inhibition activity

Doi:10.1016/j.ejmech.2011.02.059
(2011)
Synthesis of 2-substituted indoles by iridium (III)-catalyzed C–]H functionalization of N-phenylpyridin-2-amines

Doi:10.1016/j.tetlet.2019.03.027
(2019)
Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: Combining mechanism- and modeling-based design

Doi:10.1074/jbc.M110.211649
(2011)
Design of chiral sulfoxide-olefins as a new class of sulfur-based olefin ligands for asymmetric catalysis

Doi:10.1021/ol201151r
(2011)

Article Doi