Journal of Medicinal Chemistry p. 4619 - 4626 (2011)
Update date:2022-08-04
Topics:
Albers, Harald M. H. G.
Hendrickx, Loes J. D.
Van Tol, Rob J. P.
Hausmann, Jens
Perrakis, Anastassis
Ovaa, Huib
Autotaxin (ATX) is a secreted phosphodiesterase that hydrolyzes the abundant phospholipid lysophosphatidylcholine (LPC) to produce lysophosphatidic acid (LPA). The ATX-LPA signaling axis has been implicated in inflammation, fibrosis, and tumor progression
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