Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors

DOI: 10.1039/c1ob05336a

Source and publish data:

Organic and Biomolecular Chemistry p. 4144 - 4149 (2011)

Update date:2022-08-02

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Authors:

Guasconi, Margherita

Lu, Xiaoyun

Massarotti, Alberto

Caldarelli, Antonio

Ciraolo, Elisa

Tron, Gian Cesare

Hirsch, Emilio

Sorba, Giovanni

Pirali, Tracey

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Article abstract of DOI:10.1039/c1ob05336a

In a program aimed at discovering novel protein kinase inhibitors, a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines has been developed exploiting the isocyanide-based multicomponent Blackburn reaction, followed by a nucleophilic aromatic subst

Full text of DOI:10.1039/c1ob05336a

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Product name:N-(tert-butyl)-8-chloro-2-(4-nitrophenyl)imidazo[1,2-a]pyrazin-3-amine

Cas No:1312550-02-9

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