
Bioorganic and Medicinal Chemistry Letters p. 3467 - 3470 (2011)
Update date:2022-08-06
Topics:
Pike, Kurt G.
Allen, Joanne V.
Caulkett, Peter W.R.
Clarke, David S.
Donald, Craig S.
Fenwick, Mark L.
Johnson, Keith M.
Johnstone, Craig
McKerrecher, Darren
Rayner, John W.
Walker, Rolf P.
Wilson, Ingrid
The continued optimization of a series of glucokinase activators is described, including attempts to understand the interplay between molecular structure and the composite parameter of unbound clearance. These studies resulted in the discovery of a new sc
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Doi:10.1515/hc-2011-0086
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