Silver-catalyzed synthesis of disubstituted isoxazoles by cyclization of alkynyl oxime ethers

Article abstract of DOI:10.1016/j.tet.2011.04.083

A facile and practical synthesis of 3,5-disubstituted isoxazoles via a silver-catalyzed cyclization and subsequent protonation of alkynyl oxime ethers has been developed. The methodology was successfully applied to the synthesis of a biologically active i