Encapsulation of pyrene-functionalized poly(benzyl ether) dendrons into a water-soluble organometallic cage

Article abstract of DOI:10.1002/asia.201100136

Two generations of lipophilic pyrenyl functionalized poly(benzyl ether) dendrimers (P₁ and P₂) have been synthesized. The thermal properties of the two functionalized dendrimers have been investigated, and the pyrenyl group of the dendritic molecules encapsulated in the arene-ruthenium metalla-cage, [Ru₆(p-cymene)₆(tpt)₂(donq) ₃]⁶⁺ ([1]⁶⁺) (tpt=2,4,6-tri(pyridin-4-yl)-1,3, 5-triazine; donq=5,8-dioxydo-1,4-naphthoquinonato). The host-guest properties of [P₁1]⁶⁺ and [P₂1]⁶⁺ were studied in solution by NMR and UV/Vis spectroscopic methods, thus allowing the determination of the affinity constants. Moreover, the cytotoxicity of these water-soluble host-guest systems was evaluated on human ovarian cancer cells. Copyright