Preparation of peptidic α-hydroxy phosphonates. A new class of transition state analog renin inhibitors

Article abstract of DOI:10.1016/S0040-4039(00)97903-6

A stereoselective synthesis of α-hydroxy phosphonates, a new class of transition state analog inhibitors is described. Methods of incorporating neutral and basic amino acid residues at the N-terminus of α-hydroxy-β-amino dimethyl phosphonate 8 are discuss