Insertion of the fragile 2'-deoxyribosylurea residue into oligodeoxynucleotides

DOI: 10.1016/S0040-4039(00)97947-4

Source and publish data:

Tetrahedron Letters p. 5745 - 5748 (1990)

Update date:2022-08-05

Topics:

Authors:

Guy Guy

Ahmad Ahmad

Teoule Teoule

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Article abstract of DOI:10.1016/S0040-4039(00)97947-4

Deoxyribosylurea is an alkali sensitive DNA defect induced by the action of ionizing radiation. Oligonucleotides bearing this residue were synthesized using 5'-O-(4-methoxytrityl)-2'-deoxyribosylurea-3'-O-(2-cyanoethyl-N,N'-dii sopropyl)phosphoramidite and PAC protected deoxynucleoside phosphoramidites.

Full text of DOI:10.1016/S0040-4039(00)97947-4

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