Kilogram-scale asymmetric ruthenium-catalyzed hydrogenation of a tetrasubstituted fluoroenamide

DOI: 10.1002/adsc.201100195

Source and publish data:

Advanced Synthesis and Catalysis p. 3367 - 3372 (2011)

Update date:2022-07-29

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Authors:

Stumpf, Andreas

Reynolds, Mark

Sutherlin, Daniel

Babu, Srinivasan

Bappert, Erhard

Spindler, Felix

Welch, Michael

Gaudino, John

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Article abstract of DOI:10.1002/adsc.201100195

Ruthenium-catalyzed asymmetric homogeneous hydrogenation (AHH) is used as the key step of a multi-kilogram scale synthesis of an enantiomeric fluoropiperidine. The AHH of a tetrasubstituted β-fluoroenamide is carried out under mild conditions using a Ru/J

Full text of DOI:10.1002/adsc.201100195

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