
Journal of the American Chemical Society p. 2290 - 2295 (1991)
Update date:2022-08-03
Topics:
Sugiyama, Hiroshi
Sera, Takashi
Dannoue, Yukihiro
Marumoto, Ryuji
Saito, Isao
The antitumor antibiotic bleomycin (BLM) induces C-H bond scission at the C4′ of deoxyribose moiety of DNA in the presence of Fe(II) and O2. To investigate the primary oxidation step, 2′-deoxyaristeromycin (Ar) possessing a cyclopentane ring in
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