Bleomycin-Mediated Degradation of Aristeromycin-Containing DNA. Novel Dehydrogenation Activity of IronII-Bleomycin

DOI: 10.1021/ja00006a057

Source and publish data:

Journal of the American Chemical Society p. 2290 - 2295 (1991)

Update date:2022-08-03

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Authors:

Sugiyama, Hiroshi

Sera, Takashi

Dannoue, Yukihiro

Marumoto, Ryuji

Saito, Isao

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Article abstract of DOI:10.1021/ja00006a057

The antitumor antibiotic bleomycin (BLM) induces C-H bond scission at the C4′ of deoxyribose moiety of DNA in the presence of Fe(II) and O₂. To investigate the primary oxidation step, 2′-deoxyaristeromycin (Ar) possessing a cyclopentane ring in

Full text of DOI:10.1021/ja00006a057

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