Tetrahedron Letters p. 6923 - 6926 (1990)
Update date:2022-07-29
Topics:
Coulton, S.
Francois, I.
Southgate, R.
The syntheses of γ-lactam analogues of the 1-acetoxy carbapenem esters, from dl-pyroglutamic acid are described.Attempted deprotection to provide the free carboxylic acids resulted in degradation.Whilst the free acid of the 1-hydroxy carbapenem analogue was chemically stable, it lacked antibacterial activity.
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