Journal of Medicinal Chemistry p. 1155 - 1161 (1991)
Update date:2022-08-02
Topics:
Hagen, Susan E.
Domagala, Johan M.
Heifetz, Carl L.
Johnson, Judith
A series of 5-alkyl-1,7,8-trisubstituted-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids was prepared and evaluated for in vitro and in vivo antibacterial activity.When compared to the 5-hydrogen analogues, the presence of the 5-methyl group enhanc
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