Journal of Medicinal Chemistry p. 134 - 139 (1993)
Update date:2022-08-03
Topics:
Nugent, Richard A.
Murphy, Megan
Schlachter, Stephen T.
Dunn, Colin J.
Smith, Robert J.
et al.
Vinylidenebisphosphonic acid tetraethyl ester (1) and diazo ketones 7a-l in ether at 22 deg C yield pyrazoline biphosphonate tetraethyl esters 8a-l in moderate to good yield.These compounds were evaluated in animal models of arthritis: rat adjuvant-induce
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