Novel Site-Directed Affinity Ligands for GABA-Gated Chloride Channels: Synthesis, Characterization, and Molecular Modeling of 1-(Isothiocyanatophenyl)-4-tert-butyl-2,6,7-trioxabicyclooctanes

Article abstract of DOI:10.1021/jm00109a002

p-, m-, and o-Isothiocyanate derivatives (1-3, respectively) of tert-butylbicycloorthobenzoate (TBOB) were synthesized from 3-tert-butyloxethane-3-methanol (4) as the starting material.While 2 was readily obtained in four steps via catalytic hydrogenation