Novel Site-Directed Affinity Ligands for GABA-Gated Chloride Channels: Synthesis, Characterization, and Molecular Modeling of 1-(Isothiocyanatophenyl)-4-tert-butyl-2,6,7-trioxabicyclooctanes

DOI: 10.1021/jm00109a002

Source and publish data:

Journal of Medicinal Chemistry p. 1531 - 1538 (1991)

Update date:2022-08-04

Topics:

Authors:

Costa, Brian R., de

Lewin, Anita H.

Rice, Kenner C.

Skolnick, Phil

Schoenheimer, Joyce A.

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Article abstract of DOI:10.1021/jm00109a002

p-, m-, and o-Isothiocyanate derivatives (1-3, respectively) of tert-butylbicycloorthobenzoate (TBOB) were synthesized from 3-tert-butyloxethane-3-methanol (4) as the starting material.While 2 was readily obtained in four steps via catalytic hydrogenation

Full text of DOI:10.1021/jm00109a002

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