Synthesis p. 1167 - 1169 (1990)
Update date:2022-07-29
Topics:
Kanemasa
Otsuka
Doi
Tsuge
Wada
An effective synthesis of (E)-4-oxo-5-hexenals 6 and the acetals 5 starting from ethyl 2-alkoxy-1-cyclopropanecarboxylates 1a-d is presented. The acid-induced ring opening of the cyclopropanecarboxylates 1a, b followed by phosphorylmethylation or the phosphorylmethylation of the ester 1c followed by ring opening leads to the 5-acetal of 2,5-dioxopentylphosphonate 4. The Horner-Emmons olefination of 4 with various aldehydes produces the title compounds.
View Morewebsite:http://www.maisonchem.com.cn
Contact:0086-311-83833777
Address:Leitou industrial district, xinji, shijiazhuang city, hebei province,
Oren Hydrocarbons (Qingdao) Co., Ltd.
Contact:+86-532-68607667-801
Address:Room 3 # 302, No.9 Qingyun Road, Qingdao, China
Shandong Topscience Biotech Co., Ltd.
Contact:0633-2619278
Address:No. 98 Lanshan West Road, Lanshan District, Rizhao, Shandong Province, P.R. of China
Contact:+86-710-3516804
Address:Number 83,Panggong road,Xiangcheng District,Xiangyang ,Hubei
Contact:+1-284-4950244
Address:Box 3069, Road Town, Tortola, British Virgin Islands
Doi:10.1039/c1jm12071a
(2011)Doi:10.1002/anie.201308794
(2014)Doi:10.1021/ol202090a
(2011)Doi:10.1002/anie.201103007
(2011)Doi:10.1002/anie.201103261
(2011)Doi:10.1055/s-2006-949463
(2006)