4,5-Dihydropyridazin-3-one derivatives as histamine H3 receptor inverse agonists

DOI: 10.1016/j.bmcl.2011.11.037

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 194 - 198 (2012)

Update date:2022-08-04

Topics:

Authors:

Hudkins, Robert L.

Aimone, Lisa D.

Dandu, Reddeppa Reddy

Dunn, Derek

Gruner, John A.

Huang, Zeqi

Josef, Kurt A.

Lyons, Jacquelyn A.

Mathiasen, Joanne R.

Tao, Ming

Zulli, Allison L.

Raddatz, Rita

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Article abstract of DOI:10.1016/j.bmcl.2011.11.037

H₃R structure-activity relationships for a new class of 4,5-dihydropyridazin-3-one H₃R antagonists/inverse agonists are disclosed. Modification of the 4,5-dihydropyridazinone moiety to block in vivo metabolism identified 4,4-dimethyl

Full text of DOI:10.1016/j.bmcl.2011.11.037

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