ENANTIOSELECTIVE CONJUGATE ADDITION OF DIETHYLZINC TO ENONES USING CHIRAL β-AMINOALCOHOL AS CHIRAL CATALYST OR LIGAND

Article abstract of DOI:10.1016/S0040-4039(00)71227-5

Optically active β-substituted ketones of up to 94percent e.e. were synthesized by the enantioselective conjugate addition of diethylzinc to enones in the presence of either a catalyic or stoichometric amount of chiral β-aminoalcohol.