Molecular design, chemical synthesis, and biological evaluation of agents that selectively photo-degrade the transcription factor estrogen receptor-α

DOI: 10.1039/c1ob05629h

Source and publish data:

Organic and Biomolecular Chemistry p. 6357 - 6366 (2011)

Update date:2022-09-26

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Authors:

Tsumura, Kana

Suzuki, Akane

Tsuzuki, Takeo

Tanimoto, Shuho

Kaneko, Hajime

Matsumura, Shuichi

Imoto, Masaya

Umezawa, Kazuo

Takahashi, Daisuke

Toshima, Kazunobu

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Article abstract of DOI:10.1039/c1ob05629h

2-Phenylquinoline (1) degraded proteins under photo-irradiation with long-wavelength UV light without additives and under neutral conditions. We designed and synthesized a 2-phenylquinoline-estrogen receptor-α (ER-α) agonist (hybrid 2) and a 2-phenylquino

Full text of DOI:10.1039/c1ob05629h

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