Journal of the Chemical Society. Perkin transactions I p. 747 - 751 (1996)
Update date:2022-07-29
Topics:
Aitken, R. Alan
Raut, Swati V.
A series of substituted Δ2-1,2,4-oxadiazolines (4,5-dihydro-1,2,4-oxadiazoles) 12 have been prepared by 1,3-dipolar cycloaddition of nitrile oxides to imines and are found, upon treatment with KOBut, to undergo cycloreversion to give nitriles and amide anions. These can be protonated to give secondary amides or treated in situ with alkyl halides to give tertiary amides in moderate to good overall yield, although the reaction is restricted to examples with an aromatic substituent at the 5-position. The 1,4,2-dioxazoles 15, formed by cycloaddition of benzonitrile oxide to aromatic aldehydes, similarly undergo cycloreversion allowing direct conversion either into substituted benzoic acids or their methyl esters. Copyright 1996 by the Royal Society of Chemistry.
View MoreGeen Chemical Technology Co., Ltd
Contact:86-769-21660847
Address:1408, Yingfeng Commercial Center, Nancheng District
Contact:0086-357-6662688
Address:Zhaocheng town, Hongtong County, Linfen City, Shanxi Province
Huaihua Baohua Biotechnology Co.,Ltd
website:http://www.baochengchem.com
Contact:86-519-82698291
Address:HouYang chemical development zone,Jintan,Jiangsu,China (213200)
Contact:
Address:ROOM 1715, No#345 Jin Xiang Road, Pudong District
LINYI FUDE FINE CHEMICAL CO.,LTD
Contact:86-539-2361184
Address:YISHUI, LINYI,SAHNDONG,CHINA
Doi:10.1021/jo2013516
(2011)Doi:10.1080/15421406.2010.526523
(2011)Doi:10.1039/c9ob00686a
(2019)Doi:10.1016/j.tet.2011.08.019
(2011)Doi:10.1016/j.dyepig.2011.05.027
(2012)Doi:10.1246/cl.2011.944
(2011)
