Journal of the Chemical Society. Perkin transactions I p. 747 - 751 (1996)
Update date:2022-07-29
Topics:
Aitken, R. Alan
Raut, Swati V.
A series of substituted Δ2-1,2,4-oxadiazolines (4,5-dihydro-1,2,4-oxadiazoles) 12 have been prepared by 1,3-dipolar cycloaddition of nitrile oxides to imines and are found, upon treatment with KOBut, to undergo cycloreversion to give nitriles and amide anions. These can be protonated to give secondary amides or treated in situ with alkyl halides to give tertiary amides in moderate to good overall yield, although the reaction is restricted to examples with an aromatic substituent at the 5-position. The 1,4,2-dioxazoles 15, formed by cycloaddition of benzonitrile oxide to aromatic aldehydes, similarly undergo cycloreversion allowing direct conversion either into substituted benzoic acids or their methyl esters. Copyright 1996 by the Royal Society of Chemistry.
View MoreCHANGYI CITY FENGRUN FINE CHEMICAL CO.,LTD
website:http://www.fengrunhuagong.com
Contact:+86-536-7869976
Address:Changyi Coastal Economic Development Zone
SHANDONG AONA CHEMICAL CO.,LTD.
Contact:86-532-85762926
Address:LIUYUAN TOWN, ZAOZHUANG CITY, SHANGDONG PROVINCE.
Rudong Zhenfeng Yiyang Chemical Co., Ltd.
Contact:0513-84573047
Address:South Fengli Town, Rudong County, Jiangsu Province, China
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
website:http://www.shydtec.com
Contact:86-21-57721279
Address:Science and Technology Park, Songjiang District, Shanghai, China
Shanghai Forever Biotech Co., Ltd.
Contact:+86-21-69734790
Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
Doi:10.1021/jo2013516
(2011)Doi:10.1080/15421406.2010.526523
(2011)Doi:10.1039/c9ob00686a
(2019)Doi:10.1016/j.tet.2011.08.019
(2011)Doi:10.1016/j.dyepig.2011.05.027
(2012)Doi:10.1246/cl.2011.944
(2011)
