Synthesis and antiestrogenic activity of the compounds related to the metabolites of (Z)-4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-(4-isopropylphenyl)-1- butenyl]phenyl monophosphate (TAT-59)

DOI: 10.1248/cpb.39.911

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 911 - 916 (1991)

Update date:2022-07-29

Topics:

Authors:

Ogawa Ogawa

Matsushita -i.

Yamawaki

Kaneda Kaneda

Shibata Shibata

Toko Toko

Asao Asao

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Article abstract of DOI:10.1248/cpb.39.911

The metabolites of (Z)-4-[1-[4-[2-(dimethylamino)ethoxy)phenyl]-2-(4-isopropylphenyl)-1- butenyl]phenyl monophosphate, TAT-59, (1), a potent antitumor agent for hormone-dependent tumors, and derivatives of TAT-59 were synthesized to confirm its proposed s

Full text of DOI:10.1248/cpb.39.911

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