Nucleosides and Nucleotides p. 1201 - 1213 (1994)
Update date:2022-08-04
Topics: Synthesis Acyclic nucleosides Uracil 6-azauracil Antiviral agents
Wang
Chen
Tzeng
A series of acyclic nucleosides have been synthesized. Thymine, 6- azathymine, uracil, and 6-azauracil were silylated with hexamethyldisilazane in the presence of ammonium sulfate and then coupled with 1-benzyloxy-2- chloromethoxypropane to give the corresponding 1-(1-benzyloxy-2- propoxy)methyl derivatives. A minor quantity of benzyloxymethylated product was also obtained in each case. Hydrogenolysis of the protected acyclic nucleosides with palladium(II) hydroxide afforded the title compounds. None of the compounds exhibited significant antiviral activity against human immunodeficiency virus (HIV).
View MoreContact:+86-21-6856-1349 523-87676172
Address:No16 . BinJiang Road . Taixing Economy Developing Area .JiangSu Province . China
Tianjin Bright Future Technology Co., Ltd
Contact:0086-22-58016666
Address:NO.136 DongTeng Lake Street Tianjin Economic and Technology Development Area,Tainjin,China
HANGZHOU TOYOND BIOTECH CO., LTD
Contact:+86-571-86965177
Address:No. 189, Fengqi East Road, Hangzhou, China
Changzhou BaoKang Pharmaceutical & Chemical Co., Ltd
Contact:(86) 519-88782201 88784080 88785278
Address:Henglin town, changzhou,Jiangsu
Shanghai agrotree chemical co.,ltd.
Contact:+86-21-50117563
Address:Room 8A,liangfeng building,No.8 dongfang RD.pudong,shanghai,China
Doi:10.1021/acs.orglett.8b03078
(2018)Doi:10.1021/jo00028a011
(1992)Doi:10.1021/om00039a045
(1992)Doi:10.1021/jo300752c
(2012)Doi:10.1016/S0040-4039(00)73210-2
(1994)Doi:10.1021/np300292f
(2012)