Phosphoramidate protides of the anticancer agent fudr successfully deliver the preformed bioactive monophosphate in cells and confer advantage over the parent nucleoside

Article abstract of DOI:10.1021/jm200815w

The fluorinated pyrimidine family of nucleosides continues to represent major current chemotherapeutic agents for treating solid tumors. We herein report their phosphate prodrugs, ProTides, as promising new derivatives, which partially bypass the dependen