One-pot regioselective double-mannich annulations affording azabicyclononanones as a key step in the synthesis of natural products

Article abstract of DOI:10.1002/ejoc.201100700

The first regioselective one-pot syntheses of a number of azabicyclic ring systems (compounds 3) in very good yields, under green-chemistry conditions in the presence of water without use of organic solvents, through acid-catalysed double-Mannich reaction