Pseudopeptide analogues of substance P and leucine enkephalinamide containing the Ψ(CH2O) modification: Synthesis and biological activity

DOI: 10.1021/jm00112a018

Source and publish data:

Journal of Medicinal Chemistry p. 2430 - 2438 (1991)

Update date:2022-07-29

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Authors:

Roubini Roubini

Laufer Laufer

Gilon Gilon

Selinger

Roques Roques

Chorev Chorev

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Article abstract of DOI:10.1021/jm00112a018

The isosteric methyleneoxy Ψ(CH₂O) function was employed as a novel peptide-bond surrogate and incorporated into sequences of two neuropeptides, substance P (SP) and enkephalin. A pseudopeptide analogue [pGlu⁶,Phe⁸Ψ(CH View More

Full text of DOI:10.1021/jm00112a018

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