Tetrahedron p. 1697 - 1706 (1991)
Update date:2022-07-30
Topics:
Epsztajn
Bieniek
Kowalska
The synthesis and metallation (nBuLi) of 4-chloropicolin- and 2-chloroisonicotinanilides (1) and (2) as a way of regiospecific transformation of picolinic and isonicotinic acids into 2,3,4-trisubstituted pyridines (9) and (10), is described. The anilide moiety (masking group) of the formed C3-substituted chloro-anilides (9) and (10) appeared to be effectively removable on acid hydrolysis.
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Doi:10.1021/bi00859a023
(1967)Doi:10.1021/ja209354e
(2012)Doi:10.1080/00304948.2019.1577121
(2019)Doi:10.1016/S0040-4020(01)86400-0
(1991)Doi:10.1021/jm00112a013
(1991)Doi:10.1080/00397919108016757
(1991)
