Relaxant activity of 6-cyano-2,2-dimethyl-2H-1-benzopyran-4-carboxamides and -thiocarboxamides and their analogues in guinea pig trachealis

DOI: 10.1021/jm00112a037

Source and publish data:

Journal of Medicinal Chemistry p. 2588 - 2594 (1991)

Update date:2022-08-03

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Authors:

Arch Arch

Buckle Buckle

Carey Carey

Parr-Dobrzanski

Faller Faller

Foster Foster

Houge-Frydrych

Pinto Pinto

Smith Smith

Taylor Taylor

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Article abstract of DOI:10.1021/jm00112a037

Structural modifications of the potassium channel activator cromakalim (1) are described in which the amide moiety at C-4 has been replaced by carboxamide and thiocarboxamide functions. Analogues in which the hydroxyl group at C-3 has been oxidized or rem

Full text of DOI:10.1021/jm00112a037

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