5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-Chlorothien-2-yl)-2'-deoxyuridine Are Equipotent to (E)-5-(2-Bromovinyl)-2'-deoxyuridine in the Inhibition of Herpes Simplex Virus Type I Replication

DOI: 10.1021/jm00112a011

Source and publish data:

Journal of Medicinal Chemistry p. 2383 - 2389 (1991)

Update date:2022-08-04

Topics:

Authors:

Wigerinck, P.

Pannecouque, C.

Snoeck, R.

Claes, P.

Clercq, E. De

Herdewijn, P.

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Article abstract of DOI:10.1021/jm00112a011

2'-Deoxyuridines with a five-membered heterocyclic substituent in the 5-position were synthesized by palladium-catalyzed coupling reactions of 5-iodo-2'-deoxyuridine with the activated heteroaromatics.Further modification of the compound with the 5-thien-

Full text of DOI:10.1021/jm00112a011

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