Radical cyclizations of N-vinylic α-chloroacetamides. 5-Endo-trig and 4-exo-trig cyclizations

DOI: 10.1016/S0040-4039(00)74314-0

Source and publish data:

Tetrahedron Letters p. 1725 - 1728 (1991)

Update date:2022-08-04

Topics:

Authors:

Ishibashi

Nakamura

Sato Sato

Takeuchi

Ikeda Ikeda

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Article abstract of DOI:10.1016/S0040-4039(00)74314-0

Bu₃SnH mediated radical cyclizations of N-vinylic α-chloroacetamides proceeded in a ''disfavored'' 5-endo-trig manner to give five-membered lactams. Some exceptions where the 4-exo cyclization predominates are also described.

Full text of DOI:10.1016/S0040-4039(00)74314-0

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